Reverse-phase chromatography is usually adopted for the purification of polypeptide drugs, and appropriate packing material (stationary phase) is the core of the chromatographic separation:
The separation and purification of polypeptide drugs require very high performance of the packing material, so it is necessary to control the type of packing material, uniformity in pore size, particle size, homogeneity, specific surface area and functional groups. Different packing materials deliver different separation and purification results. The particle size, pore size, specific surface area and mechanical strength of silica gel packing material may affect its separation effect, even its service life.
At present, packing materials used for the purification of polypeptide/insulin products are mainly imported. The high price and long delivery period have always been a difficult problem for many polypeptide/insulin companies. To solve this problem, Dr. Wang Qunjie of Biosepur, leading his technical team, developed the Bonnasil-HS, a domestic 10 μm packing material for chromatography in line with international standards after repeated verifications and comparisons. This packing material has been proven to be used as an alternative to imported packing materials.
